PROGRAM DAY BY DAY

9:00 AM-12:00 PM  NIMH Satellite Symposium: CNS and Myeloid Cell Reservoirs

Chairs: Jeymohan Joseph NIMH, Mario Stevenson University of Miami, Miami- US

09:00- 09:05 AM – Dianne Rausch Division of AIDS Research, NIMH: Welcoming remarks

09:05- 09:15 AM – Jeymohan Joseph Division of AIDS Research, NIMH: Session Goals and NIMH Research Priorities in CNS and Myeloid Reservoirs

09:15- 09:30 AM – Thomas Hope, Northwestern University: Unexpected Outcomes in the Rebound Zone: Utilizing Correlative PET/CT and Multi-Scale Imaging to Define SIV Rebound After ART Cessation

09:30- 09:45 AM – Viviane Machado, University of Miami: Macrophage-tropic HIV-1 variants populate plasma viremia in chronic and acute subjects undergoing analytic treatment interruption.

09:45- 10:00 AM – Brooks Mitchell, University of Hawaii at Manoa Evidence of HIV Persistence in Circulating Myeloid Cells:  Implications for HIV-associated Complications and Remission

10:00- 10:15 AM – Maria Paz, University of Massachusetts Medical School. Genetic and functional differences in the CNS vs systemic HIV-1 reservoirs

10:15- 10:30 A – Kiera Clayton, Ragon Institute: HIV-infected macrophages evade NK cell-mediated killing while driving inflammation

10:30- 11:00 PM Break

11:00- 11:15 AM – Saikat Boliar, Cornell University: Targeting lncRNA SAF to induce apoptosis in HIV-1 infected macrophages

11:15- 11:30 AM – Tim Hanley, University of Utah Health Sciences Center: Low-level Persistent/Latent HIV-1 Infection of Macrophages Corresponds to Decreased NF-kB Activity

11:30- 11:45AM – Christina Gavegnano, Emory University: Effects of Blocking NOX Signaling on  HIV Persistence and HIV-associated Neurocognitive Dysfunction in a Murine HAND Model

11:45- 12:00 AM – Avi Nath NIH: Detection and modulation of HIV reservoirs in HIV infected patients on ART

9:00 AM-1:30 PM  Meeting of the Martin Delaney Collaboratories Community Advisory Board

2:00-3:30 PM  NIAID Satellite Symposium : Martin Delaney Collaboratories Research Highlights (Session 1)

3:30-4:00 PM Coffee Break

4:00-05:30 PM Satellite symposia: NIAID

5:30-05:45 CanCURE Overview

5:45-06:00 PM Break

6:00 WELCOME

  • Alain LAFEUILLADE, General Hospital, Toulon, FR

6:05-7:30 PM Opening Lecture
Introduction

Moderators: Karl SALZWEDEL, National Institute of Allergy and Infectious Diseases, Bethesda, US – Alain LAFEUILLADE, General Hospital of Toulon, FR

  • Anthony S. FAUCI, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, WA – US
  • Mike McCUNE, HIV Frontiers, Global Health Innovative Technology Solutions, Bill & Melinda Gates Foundation – US

07:30 Welcome dinner

8:00-10:00 AM – SESSION 1: Basic Science of HIV Latency

Moderators:  Una O’DOHERTY,Associate Professor Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA – US

Cellular Mechanisms that Establish and Maintain HIV Latency

Andrew HENDERSON, Professor of Medicine, Assistant Dean Graduate Medical Sciences
Department of Medicine and Microbiology, Section of Infectious Diseases Boston University School of Medicine, Boston, MA- US

10 :00-10 :30 AM Coffee Break

10:30-12:30 PM – SESSION 2: In Vitro and Animal Model Studies of HIV Persistence

Moderators :

Ann CHAHROUDI, Associate Professor Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA – US

Afam OKOYE, Research Associate Professor Vaccine & Gene Therapy Institute, and Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton – US

In vivo platforms for the evaluation of novel approaches to HIV persistence and eradication

J. Victor GARCIA MARTINEZ, Professor of Medicine, Center for AIDS Research, Division of Infectious Diseases, Chapel Hill – US

 

Understanding the establishment and persistence of the rebound competent reservoir using barcoded viruses

Brandon F. KEELE, AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick – US

12:30-2:00 PM Lunch

2:00-3:30 PM – SESSION 3: Virology of HIV persistence

Moderators :

  • Katherine BAR, Associate professor of medicine, Perelman School of Medicine, University of Pennsylvania, Pensylvania
  • Zabrina BRUMME, Director, Laboratory Program, BC Centre for Excellence in HIV/AIDS, Saint Paul Hospital, Vancouver – CAN

CD4-MBL-CAR/CXCR5 T cell immunotherapy shows promise at reducing SIV replication post-ART release

  • Pamela SKINNER, Professor Department of Veterinary and Biomedical Sciences Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program, University of Minnesota, MN – US

3.30 -4.00 PM Coffee Break

4:00 -7.00 PM – POSTER SESSION // POSTER VIEWING with wine and cheese tasting

7 :00 PM Free dinner

8:00-10:00 AM – SESSION 4: Immunology of HIV persistence

Moderators:

  • Lydie TRAUTMANN,Chief, Cellular Immunology Section I HJFIn support of the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD – US
  • Brad JONES,Assistant Professor, Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Columbia, WA – US

1st Lecturer :

  • Bruce WALKER, Founding Director of the Ragon Institute of MGH, MIT and Harvard and the Director of the Harvard University Center for AIDS Research, Cabridge, MA – US

HIV persistence during ART: Keeping memory, keeping HIV

  • Nicolas CHOMONT, Associate Professor in the Department of Microbiology and Immunology at the Université de Montréal – CHUM Research Center, Montreal – CAN

10 :00-10 :30 AM Coffee Break

10:30-12:30 PM – SESSION 5: Drug discovery and development

Moderators:

  • Bonnie HOWELL, Executive Director, Infectious Disease and Vaccines Merck, West Point, Pennsylvania, PE – US
  • Guenter KRAUS, Infectious Diseases – Research & Early Development Liaison Officer Janssen Infectious Diseases, Miami, FL – US

1st Lecturer :

Discovery and development of novel latency reversing agents

  • Richard DUNHAM, Scientific Leader and Fellow at ViiV Healthcare; Adj Asst Professor at UNC-CH Région de Raleigh-Durham, NC – US
  • Romas GELEZIUNAS, Executive Director, Biology, Foster City, CA – US

12:30-2:00 PM Lunch

2:00-3:30 PM – SESSION 6: New Therapeutic Approaches I

Moderators:

  • Ya-Chi HO, Assistant Professor of Microbial Pathogenesis and Medicine; Investigator, HIV Reservoirs and Viral Eradication Transformative Science Group (Cure TSG) New Haven, CT – US
  • Kevin MORRIS, Professor, Center for Gene Therapy, Hematologic Malignancies and Stem Cell Institute, City of Hope, Duarte, CA – US

1st Lecturer :

A viable pathway to HIV-1 remission

  • Michael FARZAN, Professor an d co-chair of the Department of Immunology and Microbiology on the Florida campus of The Scripps Research Institute, FL – US

3.30 – 4.00 PM Coffee Break

4:00 -7.00 PM – POSTER SESSION // POSTER VIEWING with wine and cheese tasting

7:00 PM Free evening

8:00-10:00 AM – SESSION 7: Human Studies

Moderators:

  • Jonathan KARN, Professor and Chair, Department of Molecular Biology and Microbiology, School of Medicine, Director, Case Center for AIDS Research, Cleveland/Akron, OH – US

1st Lecturer :

Main challenges of human studies in the HIV eradication field

  • Beatriz MOTHE PUJADAS, MD, PhD. Associate Investigator. HIV Unit & IrsiCaixa AIDS Research Institute. Hospital Germans Trias i Pujol. UVic-UC, Barcelona – ES
  • Timothy HENRICH, Associate Professor of Medicine at University of California, San Francisco, CA – US

10:00-10:30 AM Coffee Break

10:30-12:30 PM – SESSION 8: New therapeutic approaches II

Moderators:

  • Susanna VALENTE, Associate Professor Department of Immunology and Microbiology130 Scripps Way, 3C1, Jupiter, FL – US

1st Lecturer :

Genome editing against HIV

  • Paula CANNON, Professor of Molecular Microbiology & Immunology; Associate Director of Cross School Programs for the MESH Academy Molecular Microbiology and Immunology, Los Angeles, CA – USA

12:30 PM Closing ceremony